Wang Lab

Virus-Immune System Coevolution

Viruses are constantly circulating and emerging, evolving rapidly to escape immune detection. In response, immune systems continuously adapt to recognize and neutralize these threats. This dynamic interplay shapes disease outcomes and presents a major challenge for predicting viral evolution and developing effective vaccines and therapies.

Coronavirus
Influenza
Adenovirus
Rhinovirus
Herpesvirus
Rotavirus
Papillomavirus
Retrovirus
Bacteriophage

Research Directions

High-Throughput Methods & Robotic Automation

  • Yeast Display Systems
  • mRNA Display Technology
  • Deep Mutational Scanning (DMS)
  • Automated Laboratory Workflows
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Lab-Feedback AI Modeling

  • Foundation Model for Influenza Virus Evolution
  • Generative Model for Antibody Design
  • Continuous Model Refinement via Lab-Feedback
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AI Agents and Tools

  • AI Researcher (automated literature review & paper writing)
  • AI Bioinformatics (data cleaning, analysis & interpretation)
  • AI Reproduction (GitHub-mode study reproduction)
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Our Mission

We aim to create predictive models that can anticipate viral evolution and guide the development of next-generation therapeutics and vaccines.

3

Research Pillars

AI-Driven

Approach

High-Throughput

Methods

Our Team

Yiquan Wang

Principal Investigator

Dr. Yiquan Wang

Research Team

Postdocs, Graduate Students, and Collaborators

Recent Publications

Immunity cover 1

Immunity, 2022

A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2

Immunity cover 2

Immunity, 2024

An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies

Get in Touch

We are actively recruiting PhD students and postdoctoral researchers.

Email

wang.yiquan@ufl.edu

Location

Veterinary Medicine Academic Building
1945 SW 16th Ave Suite V3-111, Gainesville, FL

GitHub

https://github.com/Wang-Lab-UF