Overview of high-throughput methods and robotic automation
Core Technologies
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Yeast Display Systems: Eukaryotic display platform for screening protein-protein interactions and antibody-antigen binding with high throughput.
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mRNA Display Technology: In vitro display system that links genotype to phenotype, enabling rapid screening of protein libraries with millions of variants.
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Deep Mutational Scanning (DMS): Comprehensive analysis of protein function by systematically testing thousands of mutations in parallel.
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Automated Laboratory Workflows: Robotic systems that handle sample preparation, screening, and data collection with minimal human intervention.
Applications in Virus and Antibody Research
These high-throughput methods are powerful for studying virus-immune system interactions. We can screen thousands of antibody variants against viral targets, identify escape mutations, and characterize the functional effects of mutations across entire viral proteins.