ABOUT ME
Summary
Passionate about the integration of biological and computational sciences in the healthcare industry. Interdisciplinary research experience in diverse fields (immunology, virology, structural biology and computational biology).
I am specially interested in understanding the intricate relationship between biological sequence, structure and function. Antibodies, as a vital subtype of protein, play a pivotal role in various realms of life sciences, including the immune system, fundamental research, and therapeutic applications. My research endeavors have led me to develop cutting-edge, sequence-based deep learning models for predicting antibody functionality. My long term goal is to develop deep-learning-based pipelines to promise cheaper and faster development of novel antibodies by proposing (1) new antibody representation algorithms, (2) developing efficient antibody function (specificity;stability;affinity) prediction models, and (3) developing structure based antibody-antigen interaction models. On a parallel trajectory, I am engaged in unraveling the mechanisms underlying influenza evolution (antigenic drift/shift) through the utilization of AI models. Beyond my scientific pursuits, I hold a genuine passion for painting, design, and the arts related to life science.
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Highlighted Publications
Wang Y*, Lv H*, Lei R, Yeung YH, Shen IR, Choi D, Teo QW, Tan TJ, Gopal AB, Chen X, Graham CS. An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies. bioRxiv. 2023:2023-09.DOI: https://doi.org/10.1101/2023.09.11.557288.
Teo QW*, Wang Y*, Lv H, Tan TJ, Lei R, Mao KJ, Wu NC. Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem. Cell Reports. 2023 Nov 28;42(11).DOI: https://doi.org/10.1101/2023.07.06.547908.
Wang Y*, Yuan, M*, Lv, H, Peng, J, Wilson, IA, & Wu, NC. (2022). A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2. Immunity (2022). DOI: https://doi.org/10.1016/j.immuni.2022.03.019.
Wang Y*, Lei R*, Nourmohammad A, Wu NC. Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing. eLife 10:e72516 (2021) DOI: https://doi.org/10.7554/eLife.72516.
Awards & Fellowships
Art of Science Image Contest Winner (2024)
Biophysical Society Travel Award (2024)
“Life Inspiring” art competition Second Place Winner (2023)
HERBERT E. CARTER FELLOWSHIP (2023)
Biochemistry Department Graduate Student Conference (Travel) Awards (2022)
National Encouragement Scholarship (2015 - 2019)
"Meritorious Winner" in The Mathematical Contest in Modeling, COMAP (2017)