About Me
Research Summary
Research Topics:
Antibody Design; Viral evolution; Deep learning; Language Model; Protein Function
Passionate about the integration of biological and computational sciences in the healthcare industry. Interdisciplinary research experience in diverse fields (immunology, virology, structural biology and computational biology).
I am particularly interested in exploring the intricate relationship between biological sequences, structures, and functions. Antibodies, as a crucial subtype of proteins, play a pivotal role in various life science fields, including immunology, fundamental research, and therapeutic applications. My research focuses on developing cutting-edge, sequence-based deep learning models for predicting antibody functionality and investigating viral evolution. My long-term goal is to decode DNA to understand life more comprehensively by leveraging AI. Beyond my scientific endeavors, I am passionate about painting, design, and the arts, especially those connected to life sciences.
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Highlighted Publications
Wang Y*, Lv H*, Teo QW, Lei R, Gopal AB, Ouyang WO, Yueng YH, Tan TJC, Choi D, Shen IR, Chen X, Graham CS, Wu NC. An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies. Immunity 57:2453- 2465.e7 (2024).DOI: https://doi.org/10.1016/j.immuni.2024.07.022.
Teo QW*, Wang Y*, Lv H, Tan TJ, Lei R, Mao KJ, Wu NC. Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem. Cell Reports. 2023 Nov 28;42(11).DOI: https://doi.org/10.1101/2023.07.06.547908.
Wang Y*, Yuan, M*, Lv, H, Peng, J, Wilson, IA, & Wu, NC. (2022). A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2. Immunity (2022). DOI: https://doi.org/10.1016/j.immuni.2022.03.019.
Wang Y*, Lei R*, Nourmohammad A, Wu NC. Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing. eLife 10:e72516 (2021) DOI: https://doi.org/10.7554/eLife.72516.
Awards & Fellowships
Art of Science Image Contest Winner (2024)
Biophysical Society Travel Award (2024)
“Life Inspiring” art competition Second Place Winner (2023)
HERBERT E. CARTER FELLOWSHIP (2023)
Biochemistry Department Graduate Student Conference (Travel) Awards (2022)
National Encouragement Scholarship (2015 - 2019)
"Meritorious Winner" in The Mathematical Contest in Modeling, COMAP (2017)